The ageless brain How to sharpen and protect your mind for a lifetime

Dale E. Bredesen

Book - 2025

"From the bestselling author of The End of Alzheimer's, Dr. Dale Bredesen, comes a revolutionary new approach to preventing the onset of neurodegenerative disease and creating sustained brain health. In recent decades, advances in medicine have changed the way we think about our health. Chronic diseases like obesity, heart disease, and diabetes can be prevented or reversed. Cancer treatment has become targeted and personalized. Gene editing will allow us to eradicate many inherited disorders. But there is one class of conditions that continues to elude researchers and cause tremendous suffering: neurodegenerative disease. More than six million Americans live with Alzheimer's disease; by 2050, this number is projected to reach... thirteen million. An additional one in ten people over the age of sixty-five have dementia, while 22 percent of older adults live with some form of cognitive impairment. And it isn't just the elderly who are afflicted; diagnosis rates are rising in younger adults, with women at a higher risk than men. For many-especially those with a genetic predisposition-this fate has seemed inevitable. Until now. Dr. Dale Bredesen is a pioneer in the field of neurodegenerative research. Lauded for his integrative protocol, he has, in clinical studies, reversed the symptoms of Alzheimer's and dementia. He shared this information in his bestselling book, The End of Alzheimer's. But Dr. Bredesen doesn't want to only treat the symptoms of this devastating illness. He wants to prevent it from developing in the first place. In The Ageless Brain, Dr. Bredesen will share the latest, cutting-edge science on neurodegeneration, including how misunderstandings of the disease have hindered our efforts to treat it, as well as a preventative program that readers of all ages can put into practice to optimize their cognitive health now and sustain it for years to come. This is a book for everyone who cares about their ability to stay sharp and independent for a lifetime, for those who have witnessed family members decline, and for the many readers who are beginning to experience moments of brain fog or fatigue in middle age, and are concerned about what the future may hold. Just as bestselling authors like Dr. Peter Attia and Dr. Michael Greger have offered essential guidance for maintaining overall health and longevity, Dr. Bredesen has written the only book readers need to retain their vibrant minds-and thrive for a lifetime"-- Provided by publisher.

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  • Performance and protection
  • Adding insults to aging
  • What is possible at one hundred and beyond
  • Dying of profit
  • Identifying your why
  • A measured approach
  • Eating for an ageless brain
  • The brainspan workout
  • Cleanse and restore
  • The brain's flex factor
  • The toxic adventure
  • The microbial mind
  • Soonism
  • Prescription for an ageless brain.
Review by Publisher's Weekly Review

"How do we keep our brains youthful, healthy, and functional for the entirety of our lives?" asks neurologist Bredesen (The End of Alzheimer's) in this edifying guide. Discussing how overexposure to otherwise beneficial biological processes contributes to cognitive decline, Bredesen explains, for instance, that Alzheimer's has been linked to elevated levels of amyloid, a peptide that destroys dangerous microbes in the brain but can also cause harmful inflammation. Forming new neural connections is key for staying sharp into old age, Bredesen contends, suggesting readers might do so by taking up a new game, cooking dishes from unfamiliar cuisines, or learning a new language. The recommendations are accompanied by thorough scientific explanations, as when Bredesen advises cycling, jogging, or doing other aerobic exercises daily and describes how they heighten cerebral oxygen levels by increasing blood flow. In addition to the expected suggestions to get at least seven hours of sleep per night and eat "large portions of organic leafy greens," Bredesen also throws in some more unusual guidance. For instance, he emphasizes the importance of ridding one's home of mold, describing how fungus-produced mycotoxins impair the ability of mitochondria in human cells to generate energy. The result is a vital resource for retaining mental acuity. Agent: John Maas and Sarah Passick, Park & Fine Literary. (Mar.)

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